@article{jfnr2018693,
author={{Lee, Jongsung and Park, See-Hyoung},
title={Daidzein Has Anti-Oxidant Activity in Normal Human Kidney Tubular HK-2 Cells via FOXO3/SOD2 Pathway},
journal={Journal of Food and Nutrition Research},
volume={6},
number={9},
pages={557--560},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/9/3},
issn={2333-1240},
abstract={The anti-oxidant activity of daidzein was accessed by checking the expression level of superoxide dismutase 2 (SOD2) in HK-2 cell, a kidney proximal tubular cell line. SOD2 expression was increased in HK-2 cells treated by daidzein with a dose and time-dependent manner. Daidzein reduced the reactive oxygen species (ROS) level (about 60% compared to DMSO control with p = 0.005) in HK-2 cells. Daidzein caused FOXO3 to be translocated from cytosol into nucleus. Down-regulation of FOXO3 by transfection of siRNA against FOXO3 attenuated the expression of SOD2 and ROS level (p = 0.006) by daidzein. Taken together, this study has shown that daidzein displays anti-oxidant activity in HK-2 kidney proximal tubular cell line through up-regulation of FOXO3/SOD2 signaling pathway.},
doi={10.12691/jfnr-6-9-3}
publisher={Science and Education Publishing}
}