@article{jfnr2018686,
author={{Park, Jeongjin and Jun, Woojin and Lee, Jeongmin and Kim, Ok-Kyung},
title={Defensive Effect of Quercetin against Tumor Necrosis Factor ¦Á-induced Endoplasmic Reticulum Stress and Hepatic Insulin Resistance in HepG2 Cells},
journal={Journal of Food and Nutrition Research},
volume={6},
number={8},
pages={518--524},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/8/6},
issn={2333-1240},
abstract={In order to examine the hypothesis that the treatment of TNF-¦Á can impose inflammation and endoplasmic reticulum (ER) stress in hepatic cells, and that quercetin has a defensive effect against TNF-¦Á-induced ER stress and insulin resistance, we evaluated the effect of quercetin (3 ¦Ìg/mL and 5 ¦Ìg/mL) in the TNF-¦Á-induced HepG2 cells. The TNF-¦Á-stimulated control group caused a marked increase in the activation of inflammation and ER stress response. Quercetin, however, caused the interruption of TNF-¦Á-induced inflammation and ER stress. In addition, the treatment of quercetin resulted in significant decreases in serine phosphorylation of IRS-1, phosphorylation of JNK, and the expression of gluconeogenic genes compared with the TNF-¦Á-stimulated control group. In conclusion, we suggest that quercetin can protect hepatic insulin resistance by exerting a protective effect against the ER stress and inflammation induced by TNF-¦Á.},
doi={10.12691/jfnr-6-8-6}
publisher={Science and Education Publishing}
}