@article{jfnr2018666,
author={{Leoncini, Emanuela and Prata, Cecilia and Malaguti, Marco and Angeloni, Cristina and Massaccesi, Luca and Bosi, Sara and Bregola, Valeria and Marotti, Ilaria and Dinelli, Giovanni and Hrelia, Silvana},
title={Protective Effect of Wheat Derived Non-specific lipid-transfer Protein 2 on Vascular Endothelium Inflammation},
journal={Journal of Food and Nutrition Research},
volume={6},
number={6},
pages={386--392},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/6/6},
issn={2333-1240},
abstract={The important functions of the endothelium and the relationship between cardiovascular risk factors and endothelial dysfunction suggest the primary role of this tissue as a target for dietary strategies aimed at the prevention from related diseases. Cereals are key component of a healthy and balanced diet, and the presence of non-specific lipid-transfer protein 2 (nsLTP2) in wheat represents an added value to contribute to maintain the functionality of the vascular endothelium and consequently of the cardiovascular system. Indeed, nsLTP2 downregulates the expression of the main cell adhesion molecules induced by a pro-inflammatory cytokine and, meanwhile, upregulates heme oxigenase-1, exerting a cytoprotective/anti-inflammatory activity. Therefore, nsLTP2 might represent a food-derived tool to protect the vascular system against several pathological conditions.},
doi={10.12691/jfnr-6-6-6}
publisher={Science and Education Publishing}
}