@article{jfnr2018649,
author={{Kao, Yu-Han and Yeh, Yu-Te and Chiang, An-Na and Hsieh, Shu-Chen},
title={Study on Mechanisms Underlying the Preventive Effects of <i>Canarium album</i> L. ethanol Extract on Modulation of Hyperglycemia and Hypercholesterolemia in Diabetic Rats},
journal={Journal of Food and Nutrition Research},
volume={6},
number={4},
pages={261--270},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/4/9},
issn={2333-1240},
abstract={<i>Canarium album</i> L. has attracted attention for its high polyphenol content and various potential pharmacological activities, exhibiting potential to reduce the risk of metabolic disorders. We hypothesized that <i>Canarium album</i> L. may regulate glucose and lipid metabolic pathways. To examine the application potential of <i>Canarium album </i>L. on metabolism, we designed the present study to investigate the effect of <i>Canarium album</i> L. ethanol extract (CO-EtOH) on high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic rats. Our data showed CO-EtOH significantly reduced elevated fasting blood glucose, TC, TNF-¦Á, and bile acid. Administration of CO-EtOH increased hepatic mRNA levels of <i>GLUT2 </i>and <i>GK </i>but decreased those of <i>PEPCK</i> and <i>G6Pase</i>. Furthermore, CO-EtOH remarkably reduced hepatic levels of cholesterol; lowered the expression of genes involved in cholesterol biosynthesis, transportation, and degradation, including <i>SREBP-2</i>,<i> HMG-CoAR</i>, <i>SR-B1</i>,<i> </i><i>CYP7A1, BSEP, MRP3, MRP4, </i>and<i> NTCP</i>; and decreased the expression of <i>LDLR</i>, <i>ABCG8</i>, <i>FXR</i>, and <i>SHP </i>that<i> </i>govern cholesterol transportation and bile acid synthesis. The protein expressions of LDLR, ABCA1, FXR, and SHP were also significantly increased upon CO-EtOH treatment. Finally, CO-EtOH could increase glucose uptake in rat skeletal muscle cells in both normal and palmitic acid-challenged conditions. These findings suggest that <i>Canarium album</i> L. may have great potential for treating hyperglycemia and hypercholesterolemia.},
doi={10.12691/jfnr-6-4-9}
publisher={Science and Education Publishing}
}