@article{jfnr20186128,
author={{Lee, Jung-Ha and Lee, Jae-Bong and Lee, Jin-Tae and Park, Hae-Ryoun and Kim, Jin-Bom},
title={Medicinal Effects of Bromelain (<i>Ananas comosus</i>) Targeting Oral Environment as an Anti-oxidant and Anti-inflammatory Agent},
journal={Journal of Food and Nutrition Research},
volume={6},
number={12},
pages={773--784},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/12/8},
issn={2333-1240},
abstract={Bromelain is obtained from <i>Ananas comosus</i> and is of significant clinical interest. Many studies have demonstrated bromelain's ability to treat immune-mediated conditions including reduction of platelet aggregation, angina pectoris and surgical trauma. ROS elimination were evaluated using a variety of anti-oxidation effect tests containing DPPH assay, ABTS+ radical scavenging assay, hydrogen peroxide scavenging assay. Western blotting analysis and RT-PCR were used to investigate an anti-inflammatory agent in LPS-induced RAW cells. Treatment with bromelain exhibited significant scavenging abilities on superoxide radicals compared with control. As results of analyzing iNOS and COX-2 band appearance according to bromelain treatment, it inhibited the band expression dose-dependently. Also bromelain inhibits the phosphorylated-MAP kinases signaling pathways. Furthermore, it reduced c-Fos, phosphorylation of c-Jun and c-Jun. According to the results, it is demonstrated that bromelain of <i>Ananas comosus</i> extract have significant anti-inflammatory ability as well as antioxidant ability.},
doi={10.12691/jfnr-6-12-8}
publisher={Science and Education Publishing}
}