@article{jfnr20186124,
author={{Zaitoun, Margaret and Ghanem, Maissam and Liu, Chang and Wu, Shuqing and Cheng, Yuliang and Yao, Weirong and Guo, Yahui and Qian, He},
title={Study the Effect of Total Carotenoids from <i>Sporidiobolus pararoseus</i> on Acute Lung Inflammation in Mice Exposed to Cigarette Smoke},
journal={Journal of Food and Nutrition Research},
volume={6},
number={12},
pages={740--747},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/12/4},
issn={2333-1240},
abstract={Cigarette smoke (CS) is a major risk for chronic obstructive pulmonary disease (COPD). Pathogenesis hallmarks in the lungs of COPD patients always contribute to causing inflammation and oxidative stress. Carotenoids, extracted from <i>Sporidiobolus pararoseus</i>, have antioxidant and antitumor effect. These carotenoids have a similar structure to lycopene, which is demonstrated effective in the treatment of lung inflammation. This presented work aims to investigate the anti-inflammatory and antioxidant functions of total carotenoids (TC), extracted from <i>Sporidiobolus pararoseus</i>, on mice under a short-term exposure of cigarette smoke. Forty-eight C57BL/6 male mice were divided into 6 groups (n=8): first group was control group exposed to ambient air, second group was CS group exposed to CS, third group was CS+LY18 group exposed to CS and treated with lycopene 18 mg/kg (CS+LY18), other groups (CS+TC18, CS+TC12, CS+TC9) exposed to CS and treated with (TC) at different doses (18, 12, 9 mg/kg) respectively. Treatment with TC especially at high dosage 18 mg/kg led to decrease the levels of MDA, GSH, activities of CAT, SOD in lung samples, as well as TNF-¦Á and IL-6 levels in lungs and bronchoalveolar lavage fluid. In addition, it attenuated the morphological changes in the lungs. The high dose of TC showed a stronger effect than lycopene. These results demonstrated that TC from <i>Sporidiobolus pararoseus</i> have effective functions for acute lung inflammation induced by CS, which suggested a positive intervention for the treatment of COPD.},
doi={10.12691/jfnr-6-12-4}
publisher={Science and Education Publishing}
}