@article{jfnr20186122,
author={{Danuyanti, I Gusti Ayu Nyoman and Farmawati, Arta and Sunarti, S},
title={High Fiber Diet Suppression of TLR4 and NF百汕 Gene Expression Correlated with TNF-汐 and IL-6 Levels in Hypertriglyceridemia Rats},
journal={Journal of Food and Nutrition Research},
volume={6},
number={12},
pages={725--730},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/12/2},
issn={2333-1240},
abstract={Hypertriglyceridemia causes hypoxia and increases the release of free fatty acids in adipose tissue through lipolysis which stimulates an increase in TLR4 and NF百汕 levels as well as TNF-汐 and IL-6 secretion. The high fiber diet had a suppressing effect against TLR4 and NF百汕 gene expression and decreased TNF-汐 and IL-6 levels. This study evaluated the effect of high fiber diet (P1= 1.04 g content of fiber/rat/day, P2= 2.07 g content of fiber /rat/day and P3= 3.11 g content of fiber/rat/day) on TNF-汐 and IL-6 levels as well as expression of TLR4 and NF百汕 in rats induced by high fat and fructose diet for 6 weeks. The findings indicate that the administration of high fiber diet to the hypertriglyceridemia rats could control body weight gain and significantly reduce TNF-汐 and IL-6 levels (<i>p</i>&lt;0.05) lower than the hypertriglyceridemia groups when compared before treatment. In addition, the treatment of high fiber diet resulted in suppressing the expression of TLR4 and NF百汕 gene (<i>p</i>&lt;0.05) when compared with the normal and hypertriglyceridemia groups. The suppression of TLR4 and NF百汕 were correlated with TNF-汐 and IL-6 levels. In conclusion, the administration of the high fiber diet to the hypertriglyceridemia rats was able to decrease TNF-汐 and IL-6 levels possibly by suppression of TLR4 and NF百B gene expression.},
doi={10.12691/jfnr-6-12-2}
publisher={Science and Education Publishing}
}