@article{jfnr20186108,
author={{Wang, Hongyuan and Wang, Jin and Zhang, Zhizhou},
title={Leucine Exerts Lifespan Extension and Improvement in Three Types of Stress Resistance (Thermotolerance, Anti-Oxidation and Anti-UV Irradiation) in <i>C. </i><i>e</i><i>legans</i>},
journal={Journal of Food and Nutrition Research},
volume={6},
number={10},
pages={665--673},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/10/8},
issn={2333-1240},
abstract={Recent studies have found various compounds that can extend lifespan in different species. Amino acids as regulators in nutrition process and anti-aging have been investigated, but inconsistency existed in the literature in the context of lifespan-extending roles of some amino acids in <i>C. elegans</i>. In this paper, we measured the effects of individual branched-chain amino acids (BCAAs, leucine, valine and isoleucine) on lifespan in <i>C. elegans</i>. We found that 1000¦ÌM and 10000¦ÌM leucine could extend lifespan significantly coupled with increased stress resistance of thermotolerance, anti-oxidation and anti- UV irradiation. Furthermore, we used <i>daf-2</i> and <i>daf-16</i> mutants to explore the possible molecular mechanism of Leu-induced lifespan extension. Results suggested that the function of Leu on aging regulation is dependent on Insulin/IGF-1 (IIS) signaling. Our work confirmed that BCAAs play an important role in IIS signaling pathway to regulate aging and intake of such nutrients may also be good for healthspan in <i>C. elegans</i><i>.</i>},
doi={10.12691/jfnr-6-10-8}
publisher={Science and Education Publishing}
}