eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2017-05-31 5 6 413 417 10.12691/jfnr-5-6-8 JFNR2017568 article Ethanol Extract of Eriobotrya japonica Leaves Enhanced Swimming Capacity in Mice Heesun Jeong 1 Ok-Kyung Kim 1 Jeongjin Park 1 Kyungmi Kim 2 Jin Woong Chung 3 Sangin Shim 4 Yanghee You yyhyewha@gmail.com, wjjun@chonnam.ac.kr 4 Woojin Jun yyhyewha@gmail.com, wjjun@chonnam.ac.kr 4 Division of Food and Nutrition, Chonnam National University, Gwangju, Republic of Korea Department of Biofood Analysis, Korea Bio Polytechnic, Ganggyung, Republic of Korea Department of Biological Science, Dong-A University, Busan, Republic of Korea Division of Agriculture and Life Sciences, Gyeongsang National University, Jinju, Republic of Korea Eriobotrya japonica is known as 'Loquat' and cultivated in Korea, China, Japan, and India. The present study aims to investigate the effect of Eriobotrya japonica leaves ethanol extract (EJLE) on swimming capacity in mice. Mice were administered distilled water (EX-CON) or 1 g kg-1 per day of EJLE (EX-EJLE) for 14 days. Exhaustive swimming time was significantly prolonged (by 1.4-fold) in EX-EJLE group compared to that in EX-CON group (P < 0.05). EX-EJLE group showed high nonesterified fatty acid (NEFA) and glycogen levels during swimming (P < 0.05). When compared to EX-CON, the EX-EJLE exhibited significant increases in antioxidant enzymes activities including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and glutathione (GSH) level as well as and decrease in malondialdehyde (MDA) level (P < 0.05). EJLE elevated the mRNA expression of carnitine palmitoyltransferase-1, β-hydroxyacyl coenzymes dehydrogenase, peroxisomal proliferator activated receptors-δ, and uncoupling protein-3 in muscle (P < 0.05). These results suggest that EJLE supplementation could improve swimming capacity by ameliorate the physical exhaustion through enhancing utilization of fatty acid, facilitating lipid catabolism, and elevating antioxidant capability. http://pubs.sciepub.com/jfnr/5/6/8/jfnr-5-6-8.pdf eriobotrya japonica leaves ethanol extract swimming capacity