@article{jfnr20175126,
author={{Escobedo-Moratilla, Abraham and Velarde-Salcedo, Aida J. and Maga?a-Hern¨˘ndez, Cynthia V. and Barrera-Pacheco, Alberto and Espitia-Rangel, Eduardo and Herrera-Estrella, Alfredo and Rosa, Ana P. Barba de la},
title={Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model},
journal={Journal of Food and Nutrition Research},
volume={5},
number={12},
pages={914--924},
year={2017},
url={http://pubs.sciepub.com/jfnr/5/12/6},
issn={2333-1240},
abstract={Amaranth has been claimed as functional food, but its function on obesity-related disorder is not fully known. The aim of this study was to analyse the effect of amaranth protein intake on blood lipids profile and insulin resistance in diet-induced obese mice. The effect of soybean protein was also analysed for comparative purposes. C57BL-6 mice were fed for eight weeks with regular or high fat diet. Amaranth or soybean protein isolates (10 mg/kg) were supplied via oral administration. Changes in body weight, adipose tissue, total cholesterol, triglycerides, insulin, a glucose tolerance test, as well as the expression of lipid metabolism-related genes were measured. Our results have shown that amaranth protein induces a decrease in plasma insulin in mice fed with a regular diet, whereas a decrease in triglycerides was observed in mice fed with high fat diet. Furthermore, down-regulation of <i>Tnf-</i>&#945; and <i>Res</i>, suggested the inhibition of inflammation state. The present study demonstrates that amaranth protein, but not soybean protein, improves the obese mice health, and the hormonal modulation (<i>Lep</i>, <i>Fasn</i>, <i>Lpl</i>) could lead to new mechanism of action by which amaranth consumption exerts its beneficial health effect.},
doi={10.12691/jfnr-5-12-6}
publisher={Science and Education Publishing}
}