@article{jfnr201751110,
author={{Chou, Chung-Hsi and Lin, Hui-Wen and Wu, Yi-Hsieng Samuel and Lin, Yi-Ling and Chiang, Chia-Chun and Fu, Shih-Guei and Chen, Yi-Chen},
title={Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice},
journal={Journal of Food and Nutrition Research},
volume={5},
number={11},
pages={859--866},
year={2017},
url={http://pubs.sciepub.com/jfnr/5/11/10},
issn={2333-1240},
abstract={Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that<b> </b>OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p&lt;0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p&lt;0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, <i>Ophiocordyceps sinensis </i>mycelium (OSM) also decreased (p&lt;0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-¦Á (TNF-¦Á) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit.},
doi={10.12691/jfnr-5-11-10}
publisher={Science and Education Publishing}
}