eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2017-11-24 5 11 859 866 10.12691/jfnr-5-11-10 JFNR201751110 article Chung-Hsi Chou 1 2 Hui-Wen Lin 3 4 Yi-Hsieng Samuel Wu 5 Yi-Ling Lin 5 Chia-Chun Chiang 6 Shih-Guei Fu ycpchen@ntu.edu.tw, scottfu@mail.cnu.edu.tw 7 Yi-Chen Chen ycpchen@ntu.edu.tw, scottfu@mail.cnu.edu.tw 7 School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan Department of Optometry, Asia University, Taichung, Taiwan Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan Department of Nursing, Chung-Jen Junior College of Nursing, Health Sciences and Management, Chia-Yi County, Taiwan Department of Applied Life Science and Health, Chia Nan University of Pharmacy & Science, Tainan, Taiwan Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p<0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p<0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, Ophiocordyceps sinensis mycelium (OSM) also decreased (p<0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-α (TNF-α) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit. http://pubs.sciepub.com/jfnr/5/11/10/jfnr-5-11-10.pdf anti-inflammation high-fat diet lipid-lowering effect liver Ophiocordyceps sinensis mycelium