@article{jfnr2016499,
author={{Bouchoucha, Rim and Fradj, Mohamed Kacem Ben and Bouchoucha, Mongia and Akrout, Mouna and Feki, Moncef and Kaabachi, Naziha and Raies, Aly and Slimane, Hedia},
title={Effect of <i>Lupinus albus</i> on Glycaemic Control, Plasma Insulin Levels, Lipid Profile and Liver Enzymes in Type 2 Diabetics},
journal={Journal of Food and Nutrition Research},
volume={4},
number={9},
pages={615--620},
year={2016},
url={http://pubs.sciepub.com/jfnr/4/9/9},
issn={2333-1240},
abstract={<i>Lupinus </i>species and their derivatives are good candidates to be used as hypoglycaemic agents. The aim of this study was to evaluate the effects of supplementation with <i>Lupinus albus </i>dry extract in type 2 diabetic patients. The study included 47 adult patients (21 men and 26 women) with type 2 diabetes. While consuming their usual medication, patients received a daily dose of 400 mg of <i>Lupinus albus </i>dry extract during 12 weeks. Fasting and post meal test glucose and insulin were measured at baseline and after 2 and 12 weeks. Plasma lipids, Alanine and Aspartate aminotransferases activities and glycated haemoglobin were assessed at baseline and at the end of the supplementation period<i><b>. </b></i>Compared to baseline values, fasting and postprandial plasma glucose levels were decreased at 2 and 12 weeks. Blood glucose area under the curve significantly decreased after 2 weeks (p&lt;0.01) and 12 weeks (p&lt;0.05) of lupine administration. Fasting insulin concentrations (10.3¡À5.34 <i>vs. </i>11.9¡À6.58; p&lt;0.05) and homeostasis model assessment of insulin resistance (3.50¡À2.01 <i>vs. </i>4.40¡À2.80; p&lt;0.01) were significantly lower at 12 weeks, but not at 2 weeks. The area under the curve for insulin response did not differ from the baseline. After 12 weeks of <i>Lupinus albus</i> administration, glycated haemoglobin (-5.71%), plasma total cholesterol (-8.12%), LDL cholesterol (-5%), triglycerides (-23.2%), and Alanine aminotransferase activity (-21.1%) were significantly decreased compared to baseline. The study showed that administration of <i>Lupinus albus</i> results in a hypoglycaemic effect and an improvement of diabetes control, but does not affect insulin secretion. These findings suggest that <i>Lupinus albus</i> has insulin mimetic action.},
doi={10.12691/jfnr-4-9-9}
publisher={Science and Education Publishing}
}