@article{jfnr2016466,
author={{Hu, Ya-ya and Xing, Lu-juan and Zhou, Guang-hong and Zhang, Wan-gang},
title={Antioxidant Activity of Crude Peptides Extracted from Dry-cured Jinhua Ham},
journal={Journal of Food and Nutrition Research},
volume={4},
number={6},
pages={377--387},
year={2016},
url={http://pubs.sciepub.com/jfnr/4/6/6},
issn={2333-1240},
abstract={This study was aimed to investigate the protective effects of Jinhua ham peptide extract against oxidative damage to PC12 cells induced by H<SUB>2</SUB>O<SUB>2</SUB>. Crude peptide C (CPC) presented strong scavenging activities against DPPH radicals<SUP> </SUP><i>in vitro</i>. Exposing PC12 cells to H<SUB>2</SUB>O<SUB>2</SUB> reduced the cell viability, the activities of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), while increased the cell apoptosis. Incubating cells with different concentrations of CPC (200 and 400 ¦Ìg/mL) enhanced the cell viability and antioxidant enzyme activities. Intracellular reactive oxygen species (ROS) formation, caspase-3 activity and flow cytometric analysis revealed that CPC attenuated the cell apoptosis induced by H<SUB>2</SUB>O<SUB>2</SUB>. These cytoprotective effects of CPC on PC12 cells indicate that Jinhua ham extract might possess the ability to eliminate over-produced ROS in human.},
doi={10.12691/jfnr-4-6-6}
publisher={Science and Education Publishing}
}