@article{jfnr2016464,
author={{Kim, Ok-Kyung and Park, Jeongjin and Yoon, Ho-Geun and You, Yanghee and Seo, Yi Seul and Kim, Jae Hwan and Choi, Kyung-Chul and Lee, Yoo-Hyun and Lee, Jeongmin and Jun, Woojin},
title={Biological Activities of Fructooligosaccharides Produced by<i> Aspergillus </i><i>aculeatus</i><i> </i>in Mice Fed a High-fat Diet and Caco-2 Cell},
journal={Journal of Food and Nutrition Research},
volume={4},
number={6},
pages={361--368},
year={2016},
url={http://pubs.sciepub.com/jfnr/4/6/4},
issn={2333-1240},
abstract={We investigated the effects of the dietary supplement of fructooligosaccharides (FOS) on intestinal bacteria, blood cholesterol and mineral absorption in the Balb/c mice fed a high-fat diet.<i> </i>Mice were divided into four groups: Normal control (Balb/c mice fed normal diet), High fat control (Balb/c mice fed 60% fat diet), HF-FOS 5% (Balb/c mice fed 60% fat and 5% FOS diet), and HF-FOS 10% (Balb/c mice fed 60% fat and 10% FOS diet). We used an <i>in vitro</i> assay to evaluate whether the direct effects of FOS on calcium and magnesium transport improve absorption in the differentiated Caco-2 cell. The dietary supplementation with FOS resulted in a significant increase in <i>Lactobacillus</i> and <i>Bifidobacterium</i> in the feces and large intestine compared with the high fat control group. We found that dietary supplementation with FOS suppressed weight gain, hypercholesterolemia and hypertriglyceridemia induction by the high-fat diet although food consumption by the HF-FOS 5% and HF-FOS 10% groups was higher compared to the high fat control. Furthermore, the blood concentrations of calcium and magnesium that were lowered by the high fat diet were significantly increased in the HF-FOS 5% and HF-FOS 10% groups even though the absorption of calcium and magnesium following FOS treatment was low in the <i>in vitro</i> assay. Overall, these results suggest that dietary supplementation with FOS can help prevent a wide range of ailments induced by chronic high fat diet intake.},
doi={10.12691/jfnr-4-6-4}
publisher={Science and Education Publishing}
}