@article{jfnr20164210,
author={{Lee, Yeon-Joo and Yoon, Kye-Yoon and Lee, Ok-Hwan and Kim, Kui-Jin and Lee, Boo-Yong},
title={Polyphenol Extracted from <i>Ecklonia cava </i>Increases Insulin-mediated Glucose Uptake in 3T3-L1 Cells and Reduces Fasting Blood Glucose Levels in C57BL/KsJ db/db Mice},
journal={Journal of Food and Nutrition Research},
volume={4},
number={2},
pages={126--130},
year={2016},
url={http://pubs.sciepub.com/jfnr/4/2/10},
issn={2333-1240},
abstract={Previous study suggested that polyphenol-enriched extracts from <i>Ecklonia cava </i>(PREC, Seapolynol) have an inhibitory effect on lipid accumulation <i>in vitro</i> and <i>in vivo</i>. Based on these results, we evaluated the effect of PREC on insulin-mediated glucose uptake in 3T3-L1 cells and in male diabetic C57BL/KsJ-db/db mice. The mice were divided into four groups, including db/db, Rosiglitazone 10mg/kg/day, PREC 60mg/kg/day and PREC 150mg/kg/day. Treatment with PREC upregulated glucose uptake-associated gene expression and improved glucose uptake in fully differentiated 3T3-L1 adipocytes. Additionally, ¦Á-glucosidase (¦Á-carbohydrate-hydrolase) was inhibited by PREC in a dose-dependent manner. Moreover, PREC effectively improved GLUT4-associated gene expression and suppressed fasting blood glucose levels. These results suggest that PREC may have a mitigating effect on hyperglycaemia and could help to improve blood glucose levels in diabetes patients.},
doi={10.12691/jfnr-4-2-10}
publisher={Science and Education Publishing}
}