@article{jfnr20164104,
author={{Kim, Kui-Jin and Choi, Jia and Lee, Boo-Yong},
title={Evaluation of the Genotoxicity of a <i>Gelidium elegans</i> Extract in Vitro and in Vivo},
journal={Journal of Food and Nutrition Research},
volume={4},
number={10},
pages={653--657},
year={2016},
url={http://pubs.sciepub.com/jfnr/4/10/4},
issn={2333-1240},
abstract={<i>Gelidium elegans</i> is an edible red seaweed that exhibits a broad range of biological activities. However, there is little known about its genotoxic effects. The aim of this study was to evaluate the genotoxicity of a <i>Gelidium elegans</i> extract in three independent genotoxic tests, including a bacterial reverse mutation test, a micronucleus test, and a chromosomal aberration test. For five different strains of bacteria, the bacterial reverse mutation showed no increased reverse mutation upon exposure to 5000 ¦Ìg/plate of the <i>Gelidium elegans</i> extract. Moreover, the frequency of micronucleated bone marrow polychromatic erythrocytes (MNPCE) was not altered by the <i>Gelidium elegans</i> extract. Likewise, the chromosome aberration did not increase in response to the <i>Gelidium elegans</i> extract. Together, these genotoxicity assessment studies suggest that <i>Gelidium elegans</i> extract could be considered a safe dietary ingredient.},
doi={10.12691/jfnr-4-10-4}
publisher={Science and Education Publishing}
}