@article{jfnr2015368,
author={{Wen, Luona and Sun, Jianxia and Bai, Shun and Hu, Yunfeng and Wu, Shi and Jiao, Rui and Ou, Shiyi and Bai, Weibin},
title={Reproductive Effects of 3-Monochloropropane-1, 2-diol on Mice Sperm Function and Early Embryonic Development<i> In Vitro</i>},
journal={Journal of Food and Nutrition Research},
volume={3},
number={6},
pages={405--409},
year={2015},
url={http://pubs.sciepub.com/jfnr/3/6/8},
issn={2333-1240},
abstract={3-Monochloropropane-1, 2-diol (3-MCPD) is a well-known chloropropanol that is synthesized during food processing contamination. While evaluating sperm quality, sperm penetration into oocytes and early embryonic development, the present study investigated the effects of 3-MCPD onmicereproduction<i> in vitro</i>. During the<i>in vitro</i> fertilization (IVF) process, zygotes and 2-cell embryos were incubated with 3-MCPD-supplemented medium until 8-cell embryo formation to evaluate the reproductive toxicity of 3-MCPD. Our data showed that compared with the control group, the fertilization rate and cleavage rate remarkably decreased in groups treated with 1.802 and 3.160 mM 3-MCPD. The percentage of 2-cell embryo and 4-cell embryo formation also significantly decreased (P &lt; 0.05). Moreover, 8-cell embryos were not observed in any of the treated groups. Taken together, these results suggest that 3-MCPD exposure has hazardous effects on the micesperm fertilization ability as well as embryonic development.},
doi={10.12691/jfnr-3-6-8}
publisher={Science and Education Publishing}
}