@article{jfnr2015336,
author={{YASSIN, Magdy Hassan and Soliman, Mahamed Mohamed and Mostafa, Salama Abd-Elhafez and Ali, Hussein Abdel-Maksoud},
title={Antimicrobial Effects of Camel Milk against Some Bacterial Pathogens},
journal={Journal of Food and Nutrition Research},
volume={3},
number={3},
pages={162--168},
year={2015},
url={http://pubs.sciepub.com/jfnr/3/3/6},
issn={2333-1240},
abstract={The present study was aimed to investigate the protective effects of camel milk against pathogenicity induced by Staphylococcus aureus (<i>S. aureus</i>) and <i>E. coli</i> in Wistar rats. Sixty healthy adult male Wistar rats were divided into six groups (10 per group). Group 1 served as a control without any treatment. Group 2 received camel milk for two consecutive weeks. Group 3 injected intraperitoneally (IP) by <i>S. aureus</i> in a doses of 2x10<SUP>9 </SUP>CFU/ml per rat. Group 4 injected IP by <i>E.coli</i> in a dose of 5x10<SUP>10</SUP> CFU/ml per rat. Group 5 supplemented with camel milk for two consecutive weeks and then injected IP by <i>S.aureus</i> (2x10<SUP>9 </SUP>CFU/ml per rat). Group 6 supplemented with camel milk for two consecutive weeks and then injected IP by <i>E.coli</i> (5x10<SUP>10</SUP> CFU/ml per rat). All animals were decapitated after 3 weeks, serum was extracted and liver, kidney and lung tissues were taken for pathogen isolation. The isolation rate and pathogenicity of <i>S. aureus</i> and <i>E. coli</i> was high in rats injected pathogens alone (group 3 and 4) compared to camel milk and pathogens administered rats (group 5 and 6). The isolation of <i>S. aureus</i> and <i>E. coli</i> was high in intestine, then lung, kidney and liver. Prior camel milk supplementation ameliorated the degree of pathogenicity induced by pathogens. Camel milk had synergistic action with ciprofloxacin against <i>S. aureus</i> and <i>E. coli</i> to reduce bacterial resistance and decrease the dose of antibiotics. Pathogens injection alone induced significant amelioration in liver and kidney functions and prior camel milk administration inhibited such changes. Moreover, oxidative stress represented by the increase in malondialdehyde levels in serum of pathogens injected rats was decreased by prior camel milk administration. In conclusion, camel milk has beneficial role as antibacterial food supplement against <i>S.aureus</i> and <i>E.coli</i> pathogenicity in Wistar rats.},
doi={10.12691/jfnr-3-3-6}
publisher={Science and Education Publishing}
}