eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2015-01-28 3 1 62 68 10.12691/jfnr-3-1-11 JFNR20153111 article High Anti-oxidative and Lipid-lowering Activities of Flavonoid Glycosides-rich Extract from the Leaves of Zanthoxylum bungeanum in Multi-system Limei Ma 1 Ke Li 1 Dandan Wei 2 Hengyi Xiao 2 Hai Niu niuhai@scu.edu.cn; huangwen@scu.edu.cn 2 Wen Huang niuhai@scu.edu.cn; huangwen@scu.edu.cn 2 Institute for Nanobiomedical Technology and Membrane Biology, and Laboratory of Ethnopharmacology, Regenerative Medicine Research Center, Lab for Aging Research, West China Hospital/West China Medical School, Sichuan University, Chengdu, China College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu, China Epidemiological studies observed that Zanthoxylum bungeanum leaf, a popular vegetable in China, could interfere progression of cardiovascular diseases, especially hyperlipidemia. In the work, the pharmacological properties of Z.bungeanum leaves extract (ZLE) containing isovitexin, vitexin, hyperoside, rutin, isoquercitrin, foeniculin, trifolin, quercitrin, astragalin, and afzelin were investigated using multi-system such as mice organ tissue, HepG2 cell and apoE-/- mice. ZLE exhibited a stronger activity of scavenging free radicals. ZLE also appeared to inhibit lipid peroxidation of mice organ tissues including the heart, liver, spleen, lung, kidney, brain and pancreas. ZLE could lower lipid accumulation in HepG2 cells induced by free fatty acids (FFAs, an inducer of lipid peroxidation and free radicals production) in a dose-dependent manner. Compared with fenofibrate, a commercial product popularly used in clinical, the treatment of ZLE in apoE-/- mice had a stronger anti-hyperlipidemia without any detectable histopathological damage. This is the first report that ZLE containing high content of flavonoids with satisfying safety could significantly inhibit the development of hyperlipidemia by preventing the oxidative damage induced by free radicals and lipid peroxidation. http://pubs.sciepub.com/jfnr/3/1/11/jfnr-3-1-11.pdf Zanthoxylum bungeanum Hyperlipidemia Flavonoid glycosides HepG2 apoE-/- deficient mice