@article{jfnr20142912,
author={{Nan, Li and Kehui, Ouyang and Jiaoying, Cai and Wuying, Yang and Wenjun, Wang},
title={Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice},
journal={Journal of Food and Nutrition Research},
volume={2},
number={9},
pages={601--607},
year={2014},
url={http://pubs.sciepub.com/jfnr/2/9/12},
issn={2333-1240},
abstract={<i>Aloe</i> flavonoids exhibit various biological activities. The aim of this study was conducted to evaluate antioxidant activity and the hypolipemic mechanism of aloe flavonoids in mice. 80 hyperlipidemic mice were divided into 5 groups, each group was oral administrated with water, 4 mg/kg¡¤BW simvastatin, 100, 200, 300 mg/kg¡¤BW <i>aloe</i> flavonoids per day, respectively. Meanwhile, 16 normal mice were used as blank control, and oral administrated with water per day. After 8 weeks intervention, the concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) in the adipose and liver tissues were evaluated. Also, hormone-sensitive lipase (HSL), peroxisome proliferator-actived receptor gamma (PPAR-¦Ã), adipose triacylglyceride lipase (ATGL), and fatty acid synthase (FAS) genes expressions in the two tissues were detected by Q-PCR. The results showed that <i>aloe</i> flavonoids could decrease the TC, TG levels in the adipose and liver, while the levels of T-AOC, CAT, GSH-Px were significanly increased when compared to the control group. After treating with <i>aloe</i> flavonoids, the gene expressions of <i>HSL</i>, <i>PPAR</i>&#947;<i> </i>and <i>ATGL</i> expression enhanced, but the gene expression of <i>FAS</i> decreased when compared to the control group. In conclusion, our data showed that <i>aloe</i> flavonoids have potent hypolipemic and antioxidant activities.},
doi={10.12691/jfnr-2-9-12}
publisher={Science and Education Publishing}
}