eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2014-09-04 2 9 587 593 10.12691/jfnr-2-9-10 JFNR20142910 article Fu-Jun Jin 1 Hong-Wei Zhao 2 Xiao Yuan 2 Zhi-Yun Wu 2 Qiao-Li Wang 2 Chung-Wah Ma 2 Zhe Ren rz62@163.com; twang-yf@163.com 2 Yi-Fei Wang rz62@163.com; twang-yf@163.com 2 Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, PR China Infinitus (China) Company Co., Ltd, Guangzhou, PR China Chronic exposure to ultraviolet (UV) radiation affects diverse constituents of skin and induces photoaging. Current therapeutic approaches cannot fully reverse the pathophysiology of photoaging, thus necessitating the discovery of new strategies to protect skin from UV radiation. Natural products have long been reported to possess photoprotective effects. Herein, we investigated the potential anti-UVA effects of forsythiaside A, forsythiaside B, and phillyrin extracted from Forsythia suspensa (Thunb.) Vahl. In vitro, all three compounds significantly prevented cytotoxicity, DNA damage, apoptosis, and cell-cycle arrest caused by a low dose of UVA. All three compounds also inhibited the expression of inflammatory cytokines. Collectively, our results suggest that these three compounds could be preventives against UVA-induced skin damage. http://pubs.sciepub.com/jfnr/2/9/10/jfnr-2-9-10.pdf Forsythiaside A Forsythiaside B Phillyrin Anti-UVA Anti-inflammatory