@article{jfnr20142716,
author={{Lee, Seung-Jae and Kang, Hyun Woo and Lee, Seung Yuan and Hur, Sun Jin},
title={Green Tea Polyphenol Epigallocatechin-3-<i>O</i>-Gallate Attenuates Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Cells},
journal={Journal of Food and Nutrition Research},
volume={2},
number={7},
pages={425--428},
year={2014},
url={http://pubs.sciepub.com/jfnr/2/7/16},
issn={2333-1240},
abstract={Epigallocatechin-3-O-gallate (EGCG), the major polyphenol found in green tea, has been shown to downregulate inflammatory responses in macrophages; however, the underlying mechanism has not been understood. Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) is known to be closely correlated with the pathology of a variety of diseases and inflammations. In this study, we investigated the inhibitory effect of EGCG on NO production and its molecular mechanism in lipopolysaccharide (LPS)-stimulated macrophage RAW264.7 cells. Besides a decrease in NO secretion, protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) also decreased in LPS-stimulated RAW264.7 macrophage cells treated with EGCG. These results suggest that EGCG possesses a potent anti-inflammatory activity.},
doi={10.12691/jfnr-2-7-16}
publisher={Science and Education Publishing}
}