@article{jfnr2014235,
author={{Zhang, Yanqing and Ma, Guijie and Fang, Leilei and Wang, Lijuan and Xie, Junbo},
title={The Immunostimulatory and Anti-tumor Activities of Polysaccharide from <i>Agaricus bisporus</i> (brown)},
journal={Journal of Food and Nutrition Research},
volume={2},
number={3},
pages={122--126},
year={2014},
url={http://pubs.sciepub.com/jfnr/2/3/5},
issn={2333-1240},
abstract={<i>Agaricus bisporus</i>?is one of the most consumed culinary mushrooms in the world. The white type of <i>Agaricus bisporus</i> has been demonstrated with various bioactivities beneficial to human health. However, little was known about its brown type. In this study, the anti-cancer and immunoregulatory potential of Agaricus bisporus?(brown) polysaccharide were investigated <i>in vitro</i> and <i>in vivo</i>. <i>In vitro</i>, the polysaccharide had a significant antiproliferative effect on Hela cells (cervical cancer cells), especially at the high concentration of 200 ¦Ìg/ml. The spleen index, thymus index and carbon clearance ability of mice were remarkably increased by the polysaccharide treatment, indicating the polysaccharide had a promising benefit for immunodulation <i>in vivo</i>. Furthermore, the polysaccharide increased the proliferation of RAW264.7 cells with 19.1% at 50¦Ìg /ml and 34.5% at 100¦Ìg /ml, which demonstrated the immunodulation mechanism was in close conjunction with macrophages. In conclusion, these results indicated that Agaricus bisporus (brown) polysaccharide possessed strong immunostimulatory and anti-tumor bioactivity <i>in vivo</i> and <i>in vitro</i>. Therefore, it could be explored as a novel natural antitumor agent with immunomodulatory activity.},
doi={10.12691/jfnr-2-3-5}
publisher={Science and Education Publishing}
}