@article{jfnr20142113,
author={{Yoon, Yeo Cho and Kim, Sung-Hee and Hwang, Jin-Taek and Sung, Mi Jeong and Kim, Myung-Sunny and Hur, Haeng Jeon and Rhyu, Mee Ra and Park, Jae-Ho},
title={Ethanol Extract of <i>Polygonatumofficinale</i> Rhizome Inhibits Odorant-Induced Camp and Calcium Levels in Non-Chemosensory 3T3-L1 Cells},
journal={Journal of Food and Nutrition Research},
volume={2},
number={11},
pages={776--780},
year={2014},
url={http://pubs.sciepub.com/jfnr/2/11/3},
issn={2333-1240},
abstract={Polygonatum Officinalerhizome, a member of the liliaceae family, is commonly consumed as tea in Asia. It is also clinically used to treat obesity and fatigue in Korean traditional medicine. Although the anti-diabetic effect of POR has been described, little is known about its physiological role in the olfactory system. In this study, we investigated the effects of POR in 3T3-L1 cells expressing an odorant receptor. We have shown that the levels of cAMP and Ca<SUP>2+</SUP> and the phosphorylation of Rap1A and CREB increased in response to an odorant, eugenol. POR significantly decreased the eugenol-induced increase in cAMP and Ca<SUP>2+</SUP>. Taken together, these data suggest that POR inhibits an odorant-induced signal transduction pathway.},
doi={10.12691/jfnr-2-11-3}
publisher={Science and Education Publishing}
}