Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2 11 2014 10 20 Ethanol Extract of Polygonatumofficinale Rhizome Inhibits Odorant-Induced Camp and Calcium Levels in Non-Chemosensory 3T3-L1 Cells 776 780 EN Yeo Cho Yoon Sung-Hee Kim Jin-Taek Hwang Mi Jeong Sung Myung-Sunny Kim Haeng Jeon Hur Mee Ra Rhyu Jae-Ho Park Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea JFNR20142113 10.12691/jfnr-2-11-3 2014 08 12 2014 10 05 2014 10 20 Polygonatum Officinalerhizome, a member of the liliaceae family, is commonly consumed as tea in Asia. It is also clinically used to treat obesity and fatigue in Korean traditional medicine. Although the anti-diabetic effect of POR has been described, little is known about its physiological role in the olfactory system. In this study, we investigated the effects of POR in 3T3-L1 cells expressing an odorant receptor. We have shown that the levels of cAMP and Ca2+ and the phosphorylation of Rap1A and CREB increased in response to an odorant, eugenol. POR significantly decreased the eugenol-induced increase in cAMP and Ca2+. Taken together, these data suggest that POR inhibits an odorant-induced signal transduction pathway.