eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2014-10-20 2 11 776 780 10.12691/jfnr-2-11-3 JFNR20142113 article Yeo Cho Yoon 1 Sung-Hee Kim 1 Jin-Taek Hwang 1 Mi Jeong Sung 1 Myung-Sunny Kim 1 Haeng Jeon Hur 1 Mee Ra Rhyu 1 Jae-Ho Park jaehoparkmail@gmail.com 1 Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea Polygonatum Officinalerhizome, a member of the liliaceae family, is commonly consumed as tea in Asia. It is also clinically used to treat obesity and fatigue in Korean traditional medicine. Although the anti-diabetic effect of POR has been described, little is known about its physiological role in the olfactory system. In this study, we investigated the effects of POR in 3T3-L1 cells expressing an odorant receptor. We have shown that the levels of cAMP and Ca2+ and the phosphorylation of Rap1A and CREB increased in response to an odorant, eugenol. POR significantly decreased the eugenol-induced increase in cAMP and Ca2+. Taken together, these data suggest that POR inhibits an odorant-induced signal transduction pathway. http://pubs.sciepub.com/jfnr/2/11/3/jfnr-2-11-3.pdf cAMP adenylyl cyclase olfactory polygonatumofficinale 3T3-L1