@article{jfnr20251384,
author={{Ishido, Keiichi and Sasakawa, Yuka and Abe, Michiyo and Nakaoka, Fumiko and Nakao, Mayumi and Yamamoto, Kaori and Fukuhama, Chizuko and Sumida, Yasuo},
title={Identification of Glyasperin B as a Lipolytic Agent with Anti-Obesity Activity from the Licorice Extract of <i>Glycyrrhiza uralensis</i>},
journal={Journal of Food and Nutrition Research},
volume={13},
number={8},
pages={301--306},
year={2025},
url={https://pubs.sciepub.com/jfnr/13/8/4},
issn={2333-1240},
abstract={<b>  </b>Obesity is recognized as a significant public health concern. Although licorice extract from the root of <i>Glycyrrhiza uralensis</i> exhibits anti-obesity effects, limited knowledge regarding its active components has hindered the development of standardized preparations. Therefore, this study aimed to identify the compound responsible for the anti-obesity activity of licorice extract. By isolating and characterizing a compound exhibiting lipolytic activity against 3T3-L1 adipocytes, glyasperin B was identified. In a diet-induced obesity mouse model, the efficacy of licorice extracts correlated with glyasperin B content, suggesting that glyasperin B is a key contributor to the anti-obesity effects of <i>Glycyrrhiza uralensis</i>. This study¡¯s findings may facilitate the standardized preparation of licorice extracts for weight management, potentially aiding in the fight against obesity.},
doi={10.12691/jfnr-13-8-4}
publisher={Science and Education Publishing}
}