@article{jfnr20251322,
author={{Alneghery, Lina M. and Al-Zharani, Mohammed and Mubarak, Mohammed and Aljarba, Nada H. and Rudayni, Hassan and Almuqri, Eman and Yaseen, Khadijah and Albatli, Shaikha A. and Alkahtani, Saad and Nasr, Fahd A. and Al-Doaiss, Amin A. and Al-eissa, Mohammed S.},
title={The Antioxidant Properties of Resveratrol Effectively Mitigate Cadmium-Induced Oxidative Stress by Enhancing the Endogenous Antioxidant Capacity in Wistar Rats},
journal={Journal of Food and Nutrition Research},
volume={13},
number={2},
pages={61--69},
year={2025},
url={https://pubs.sciepub.com/jfnr/13/2/2},
issn={2333-1240},
abstract={Resveratrol is a phytochemical found in red grapes, berries, and certain microorganisms. This naturally occurring bioactive polyphenolic compound is known for its various biological activities. The current study aimed to evaluate resveratrol's in vivo antioxidant properties and its effectiveness in reducing oxidative stress caused by cadmium exposure. In the experiment, rats were divided into four groups (n=20): an untreated control group, a resveratrol-treated group, a cadmium-exposed group, and a cadmium-resveratrol group. Hematological and biochemical assays were conducted to meet the study's objectives. The haematological and biochemical profiles of the cadmium-exposed rats (Group 3) showed significant changes, including increases and decreases, compared to the untreated control group. In the biochemical profile analysis of serum, the resveratrol-treated animals in Group 2 displayed no significant differences relative to the untreated control. In contrast, rats in Group 4 (the cadmium-exposed and resveratrol-treated group) exhibited elevated levels of total proteins and marked increases in antioxidant markers, including total thiols, glutathione, total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase. Additionally, this group showed a substantial reduction in blood cadmium levels and lower concentrations of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, blood urea nitrogen (BUN), urea, bilirubin, and oxidative stress markers such as hydrogen peroxide (H2O2) and malondialdehyde (MDA) compared to the cadmium-exposed animals (Group 3). Results from tissue homogenate analysis of the liver and kidneys in Group 3 were consistent with the serum biochemical findings. These results suggest that resveratrol possesses potent antioxidant properties that effectively mitigate oxidative stress resulting from cadmium exposure.},
doi={10.12691/jfnr-13-2-2}
publisher={Science and Education Publishing}
}