@article{jfnr20231185,
author={{Rebai, Ouafa and Amari, Nesrine Ouda and Missoun, Fatiha},
title={Identification of the Anti-inflammatory and Wound Healing Effects of <i>Cordyceps militaris</i> Extract in Animal Models},
journal={Journal of Food and Nutrition Research},
volume={11},
number={8},
pages={549--556},
year={2023},
url={http://pubs.sciepub.com/jfnr/11/8/5},
issn={2333-1240},
abstract={<i>Cordyceps militaris</i>?is one of the most well known medicinal entomopathogenic fungi and as such has been widely used for the treatment of various diseases. However, the pharmacological and biochemical activities of?<i>C. militaris</i>?have not been clearly elucidated. The evaluation of the anti-inflammatory activity of <i>C. militaris</i> was performed by the test for plantar edema induced by injection of carrageenan in mice. The percentage inhibition of edema and the percentage increase in paw edema volume were then evaluated. Wound healing effect of <i>C. militaris</i> extract was studied on an excision wound model in rats. Changes in wound area were measured regularly and the rate of wound contraction calculated, then the histopathological recovery was evaluated. The results in all animals were not shown signs of toxic e?ects, moribund, and mortality. Oral administration of <i>C. militaris</i> extract reduced significantly after 2 hours the paw edema induced by carrageenan in mice (8.96¡À2.83%, 6.25¡À2.70% and 4.92¡À2.22 % at doses of 100, 200 and 300mg/kg BW respectively); the histological study confirmed the decrease in inflammatory response. Topical application of <i>C. militaris</i> ointments at 5% and 10% showed an enhance rate of contraction and significantly decreased wound area than control group. With histological evidence of more collagen formation in the skin and early epithelization period with low scar area. <i>C. militaris</i> mushrooms de?nitely deserve to be considered as functional foods and also have great potential for medicinal use.},
doi={10.12691/jfnr-11-8-5}
publisher={Science and Education Publishing}
}