@article{jfnr20231181,
author={{Lozano-Cuenca, Jair and L¨®pez-Canales, Oscar Alberto and Miliar-Garc¨ªa, ¨¢ngel and Mart¨ªnez¨CGod¨ªnez, Mar¨ªa de los ¨¢ngeles and Teran-Gallardo, Osiris and Paredes-Carbajal, Mar¨ªa Cristina and L¨®pez-Mayorga, Ruth Mery and Castillo-Henkel, Enrique Fernando and Flores-Herrera, H¨¦ctor and L¨®pez-Canales, Jorge Skiold},
title={Endothelium-Dependent Vasorelaxant Effect of a Bioactive Tripeptide, Valine-Proline-Proline, on Rat Aortic Rings},
journal={Journal of Food and Nutrition Research},
volume={11},
number={8},
pages={519--524},
year={2023},
url={http://pubs.sciepub.com/jfnr/11/8/1},
issn={2333-1240},
abstract={The aim of this study was to gain further insights into the mechanisms responsible for the Val-Pro-Pro-induced vasodilation of rat aortic rings. The vasorelaxant effect was found at 10-9-10-4 M of the tripeptide on phenylephrine-precontracted rings. It was endothelium-dependent and concentration-dependent at the higher concentrations. The vasodilator response was not modified by preincubation with 3.1 x 10-7 M glibenclamide, 10-3 M 4-aminopyridine (4-AP), 10-5 M indomethacin or 10-5 M cycloheximide. However, this response was significantly diminished by preincubation with 10-5 M L-NG-Nitroarginine methyl ester (L-NAME), 10-7 M 1H-(1,2,4)oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), 10-6 M (9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i]benzodiazocine-10-carboxylic acid, methyl ester (KT 5823), 10-2 M tetraethylammonium (TEA) and 10-7 M apamin plus 10-7 M charybdotoxin, as well as by the removal of the vascular endothelium. Apparently, Val-Pro-Pro directly produced vasorelaxation of phenylephrine-precontracted rat aortic rings by stimulating the vascular endothelium and activating the NO/cGMP/PKG/Ca2+-activated K+ channel pathway.},
doi={10.12691/jfnr-11-8-1}
publisher={Science and Education Publishing}
}