@article{jfnr20231164,
author={{Neves, Josyanne Ara¨²jo and Silva, Francilene Vieira da and Fernandes, H¨¦lio Barros and Viana, Ana Fl¨¢via Seraine Cust¨®dio and Neves, Josynaria Ara¨²jo and Piauilino, Celyane Alves and Neto, Benedito Pereira de Sousa and Lopes, Joselma Sousa Lacerda and Sousa, Aline Jeane Costa and Sousa, Ma¨ªsa Campelo de and Torres, Lucillia Rabelo de Oliveira and L¨®pez-Hern¨¢ndez, Julia and Quir¨®s, Ana Rodriguez-Bernaldo de and Garcia, Raquel Send¨®n and Oliveira, Rita de C¨¢ssia Meneses},
title={Phenolic Profile, Antioxidant, Gastroprotective and Ulcer Healing Activities of Pot-pollen Produced by the Stingless Bee [<i>Melipona compressipes </i><i>fasciculata</i> (Smith, 1854)]},
journal={Journal of Food and Nutrition Research},
volume={11},
number={6},
pages={423--435},
year={2023},
url={http://pubs.sciepub.com/jfnr/11/6/4},
issn={2333-1240},
abstract={The gastric ulcer is definited as erosion of the stomach's mucosal wall, which affects over 4.6 million people per year. The objective was to investigate the phenolic profile and the antioxidant activity of <i><b>Melipona compressipes</b></i> fasciculata pot-pollen collected at seasons rainy (PPMF1) and dry (PPMF2), as well as the gastroprotective and ulcer healing activities of PPMF2, as <b>PP</b><b>M</b><b>F1</b> did not have a gastroprotective effect in screening protocols. The phenolic profile revealed compounds such as caffeic acid, quercetin, myricetin and naringenin. In models of gastric lesions by ethanol, ischemia/reperfusion (I/R) and acetic acid, PPMF2 reduced the lesion area (at doses 3 to 80 mg/kg, p.o.) and volume at doses (3 to 24 mg/kg, p.o.) with protection at percent 52 to 92%. PPMF2 too, significantly (p&lt;0.05) elevated mucus and non-protein sulfhydryl groups (SH-NP) with an increase of 122% and 92% respectivelly compared to vehicle group, and decreased malonaldehyde (MDA) in rats (36% compared to vehicle group). As for cicatrizant activity in acetic acid-induced ulcer, PPMF2 promoted healing rates until 97%, caused significant microscopic gastric recovery, elevation of SH-NP (103%), attenuation of MDA (84%) levels and improvement of biochemical profile (p&lt;0.05). This is a relevant and pioneering research associating stingless bee (<i>M. compressipes fasciculata</i>) in gastroprotective activity studies.},
doi={10.12691/jfnr-11-6-4}
publisher={Science and Education Publishing}
}