@article{jfnr20231123,
author={{Jesadaporn, Panas and Somlaw, Nicha and Petchlorlian, Aisawan and Boonsawat, Natthapapath and Buranapin, Supawan and Varothai, Narittaya},
title={Effects of High-protein, Leucine-enriched Oral Nutritional Supplement and Resistance Exercise on Physical Performance among Malnourished Older Adults with Sarcopenia},
journal={Journal of Food and Nutrition Research},
volume={11},
number={2},
pages={125--135},
year={2023},
url={http://pubs.sciepub.com/jfnr/11/2/3},
issn={2333-1240},
abstract={<b>Background:</b> Malnutrition combined with sarcopenia among older adults has resulted in poor outcomes, diminished quality of life (QoL), and increased mortality rates. Inadequate calorie and protein intake are factors contributing to sarcopenia. Specific nutritional interventions and exercise regimens may improve muscle strength and health outcomes. <b>Aim:</b> To determine the effects of a high-protein, leucine-enriched oral nutritional supplement (ONS) and resistance training (RT) on physical performance, muscle strength, QoL, and other outcomes among adults with sarcopenia. <b>Methods:</b> This was a single arm, open-label, 12-week prospective, multicenter study that involved outpatient malnourished older adults with sarcopenia from four hospitals in Thailand. During the 12-week period, subjects were given two servings of high-protein, leucine-enriched ONS per day with RT four times/week. Accordingly, short physical performance battery (SPPB), hand grip strength, muscle mass by dual-energy x-ray absorptiometry (DXA), QoL, frailty, and functional status of all subjects were assessed. <b>Results:</b> A total of 47 participants were enrolled in this study. After 12 weeks, 5-time chair stand results decreased from 11.59 ¡À 3.31 to 8.97 ¡À 1.85 seconds (p&lt;0.001), SPPB scores increased from 10.64 ¡À 1.51 to 11.84 ¡À 0.43 (p&lt;0.001), hand grip strength increased from 20.24 ¡À 5.69 to 21.96 ¡À 5.75 kg (p&lt;0.001), and appendicular lean mass index values increased from 5.15 ¡À 0.67 to 5.41 ¡À 0.93 kg/m2 (p=0.004). Recovery from sarcopenia was observed in 80% of the subjects. QoL and frailty improved significantly. Moreover, MNA scores changed from 21.63 ¡À 2.10 to 25.53 ¡À 2.01 (p&lt;0.001). Caloric and protein intake values changed from 26.25 ¡À 8.77 to 35.21 ¡À 8.23 kcal/kg/day and 1.10 ¡À 0.51 to 1.60 ¡À 0.35 g/kg/day, respectively (p&lt;0.001 both). <b>Conclusions:</b> High-protein, leucine-enriched ONS and RT have benefits for malnourished sarcopenic older adults through improvements in physical performance, muscle strength, muscle mass, recovery rates from malnutrition, frailty, and QoL.},
doi={10.12691/jfnr-11-2-3}
publisher={Science and Education Publishing}
}