@article{jfnr20221045,
author={{Chu, Thi Thu Hien and Nguyen, Hai Thuy and Phu, Thi Hoa and Tran, Huu Dung and Tran, Manh Hung},
title={Effect of Acetylated Wheat Starch on Metabolic Indices in High-Fat Diet-induced Obese and Hyperglycemic Mice},
journal={Journal of Food and Nutrition Research},
volume={10},
number={4},
pages={293--298},
year={2022},
url={http://pubs.sciepub.com/jfnr/10/4/5},
issn={2333-1240},
abstract={Resistant starches are commercially available as food ingredients for diabetic and obese patients; however, the effects of acetylated wheat starch on digestive enzymes and the glucose-insulin response both <i>in vitro</i> and <i>in vivo</i> require additional evidence.<b> </b>The goal of this study was to evaluate the effects of acetylated wheat starch (AWS) on blood glucose and insulin responses in high-fat diet (HFD)-induced obese and hyperglycemic mice. <i>In vitro</i> determination of ¦Á-amylase and amyloglucosidase resistance was performed according to AOAC 2002.02. <SUP> </SUP>Obese and hyperglycemic conditions were induced by HFD containing 52.1% fat. Postprandial blood glucose level, intraperitoneal glucose tolerance test (IPGTT), intraperitoneal insulin tolerance test (IPITT), homeostatic model assessment, and insulin resistance (HOMA-IR) were performed to evaluate the effects of AWS on glucose-insulin response after a single dose or repeated dose of AWS treatment and compared with normal wheat starch (NWS). The results showed that AWS contained a higher ratio of resistant starch (32.11 ¡À 0.99%) in comparison to NWS (7.36 ¡À 0.65%) (p &lt; 0.05). The HFD induced significant metabolic alterations, including obesity and-, increased blood glucose (¡Ý 8.3 mmol/L), triglyceride (¡Ý 30% vs. control), and insulin levels. In the single-dose treatment protocol in obese, hyperglycemic mice, both postprandial blood glucose and its area under curve (AUC)<SUB>0-120min</SUB> values were significantly lower in the AWS-fed group than in the control (NWS-fed) group (p &lt; 0.05). Long-term (8-week) treatment with AWS in obese, hyperglycemic mice significantly lowered body weight, blood glucose levels, and AUC values compared with those of the NWS group (p &lt; 0.05). There was a significant decrease in the HOMA-IR index and AUC value during IPGTT and IPITT in the AWS-treated groups. This study demonstrated that AWS exerted more beneficial effects than NWS in obese and hyperglycemic mice, including weight loss, improved glucose-, and insulin tolerance, and reduced insulin resistance.},
doi={10.12691/jfnr-10-4-5}
publisher={Science and Education Publishing}
}