@article{jfnr202210103,
author={{Zhou, Jie and Chang, Shuyi and Zhang, Qianxi and Lu, Lianxiao and Li, Long and Li, Zhicheng},
title={Five Natural Active Ingredients Achieve Anti-fatigue Function by Synergistic Antioxidation and Regulating the Structure of Intestinal Flora},
journal={Journal of Food and Nutrition Research},
volume={10},
number={10},
pages={655--663},
year={2022},
url={http://pubs.sciepub.com/jfnr/10/10/3},
issn={2333-1240},
abstract={In this study, the synergistic anti-fatigue effects of five natural active ingredients (anthocyanin, tea polyphenol, Lycium barbarum polysaccharide, ginsenoside, salidroside) and their effects on intestinal flora in mice were investigated. Synergistic antioxidant <i>in vitro</i> showed that when ginsenoside: Lycium barbarum polysaccharide: salidroside = 2:1:6 (4 mg/mL), the maximum experimental scavenging capacity (ESC) of the system was 124.73¡À5.32 ¦̀mol Trolox/L, the synergistic effect (SE) was 2.75. Natural active ingredients of different concentrations and formulations were orally administered to mice. The results showed that compared with control group, the group H (Ginsenoside/Lycium barbarum polysaccharide/Salidroside (2/1/6) 200 mg kg<SUP>-1</SUP> d<SUP>-1</SUP>) can significantly increase the exhausting swimming time, decreasing the content of blood lactic acid (BLA), serum urea nitrogen (BUN), and malondialdehyde (MDA), which were accompanied by a corresponding increase in liver superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), liver glycogen content (LG) (<i>p </i><i>&lt; </i>0.05). The relative abundances of <i>Verrucomicrobiota</i> and <i>Rokubacteria</i> in group H were significantly decreased (<i>p</i> &lt; 0.05), and the relative abundances of <i>Acidobacteria</i>, <i>Parasutterella</i> and <i>Deferribacteres</i> were significantly increased (<i>p</i> &lt; 0.05). These data suggest that ginsenoside, Lycium barbarum polysaccharide, and salidroside achieve synergistic anti-fatigue effects by regulating intestinal flora and oxidative stress.},
doi={10.12691/jfnr-10-10-3}
publisher={Science and Education Publishing}
}