eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2021-12-30 10 1 8 18 10.12691/jfnr-10-1-2 JFNR20221012 article Min Jung Kim 1 Kwang-Hyun Park pkh15129@gmail.com; yhj@kfri.re.kr 2 3 Hye Jeong Yang pkh15129@gmail.com; yhj@kfri.re.kr 3 Dai Ja Jang 3 Hak Yong Lee 4 Young Mi Park 4 Byeong Soo Kim 5 Dong Yeop Shin 5 5 Korea Food Research Institute, 245, Wanju, Jeonbuk, 55365, Korea BioMedical Science Graduate Program (BMSGP), Chonnam National University, Hwasun, 58128, Korea INVIVO Co. Ltd., 121, Deahak-ro, Nonsan, Chungnam, 32992, Korea Department of Integrated Life Science and Technology, Kongju National University, 32439, Korea Schisandrae chinensis (Omija) is traditionally used as a food-based medicinal/pharmaceutical resources including antidiabetic agent in worldwide. In this study, the optimal combined formula of Omija extract and soybean mixture (OSM) were investigated for its effects on type 2 diabetes model expressed in in Vitro and in Vivo animal model. Using whole extracts, we confirmed inhibitory effects to ¦Á-glucosidase, ¦Á-amylase and the DPPH scavenging in Vitro and examined glucose tolerance in mice. The combined optimum formulation of OSM were significantly ameliorated type 2 diabetes-related. Furthermore, activation of p-Akt, p-AMPK, p-IRS and GLUT2 expression level is pivotal roles of in this anti-diabetic molecular mechanism on in Vivo without side effects. Therefore, these results suggest that OSM is good resources for improves of type 2 diabetes and its complications. http://pubs.sciepub.com/jfnr/10/1/2/jfnr-10-1-2.pdf Schisandrae chinensis type 2 diabetes diabetes complication db/db mice antioxidant combined mixture