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Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
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Biomedical Science and Engineering

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Natural Plants and Cancer Therapy

Ahmed M. Kabel

Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

Abstract: Cancer chemotherapy represents the cornerstone of management of a vast majority of neoplastic lesions. Adverse reactions of chemotherapy may affect the major body organs and represent deleterious health hazards for cancer patients. Recent studies are directed towards discovery of natural compounds of plant origin that have potential anticancer properties and may ameliorate the toxic effects induced by the traditional anticancer agents. This manuscript throws light on the potential role of the natural plants in cancer therapy.

Keywords: natural, plants, cancer

Received August 13, 2020; Revised September 16, 2020; Accepted September 25, 2020

Citation: Ahmed M. Kabel, Natural Plants and Cancer Therapy. Journal of Cancer Research and Treatment, 8 (2). 33-34. January 2020. doi:10.12691/jcrt-8-2-5

The chemotherapeutic agents represent essential weapons for combating different types of malignancies [1]. However, the adverse effects induced by these agents represent an obstacle against their role in management of cancer [2]. These adverse effects depend mainly on the type of the drug itself and on the doses administered to the patients [3]. To decrease the dose and toxicity and increase the efficacy of the traditional chemotherapeutic agents, different lines were investigated [2]. Searching for natural agents that have potent anticancer properties may play a crucial role in amelioration of the adverse effects induced by the traditional anticancer agents [4].

The antitumor properties of a wide variety of plants had been investigated for centuries [3,5]. An example include podophyllotoxin and other compounds which were isolated from Podophyllumpeltatum and participated efficiently in the development of drugs used to treat carcinoma of the lung and testis [6]. The chemopreventive effects of the natural plants were widely investigated such as the effect of Asparagus racemosa in human epidermoid carcinoma, Erthyrinasuberosa in sarcoma, Anacardiumoccidentale in hepatoma, Euphorbia hirta in Freund virus leukemia, Boswelliaserrata in human epidermal carcinoma of the nasopharynx, and Nigella sativa in lung carcinoma [7]. These studies attributed the antitumor effects of these plants to their antioxidant and anti-inflammatory properties together with their ability to affect the cell cycle and induce the expression of the antiapoptotic agents [8]. The main advantage of these agents is that they are nearly devoid of adverse effect which gives them an important role in management of different types of cancer [9].

Recent studies reported that natural agents may sensitize the tumor cells to the effect of the chemotherapeutic agents, decrease the drug efflux or enhance accumulation of the chemotherapeutic agents in cancer cells, and promote the mechanisms by which the normal cells can repair the damage induced by the chemotherapeutic agents [10]. Using the traditional herbal medicine as a chemotherapeutic adjuvant was proven to improve the quality of life of cancer patients, ameliorate bone marrow depression, and possibly decrease the mortality rates [11]. However, the occurence of herbal–drug interactions may induce toxic events that may cause liver or kidney injury that necessitate taking great caution during new drug discovery and development [2]. Further studies are needed to look for herbal agents that can be used as an effective supplement for the chemotherapeutic agents to ameliorate any adverse effects and overcome resistance of cancer cells to chemotherapy.

References

[1]   | Kabel AM, Omar MS, Balaha MF, Borg HM. Effect of metformin and adriamycin on transplantable tumor model. Tissue Cell 2015; 47(5): 498-505.
[2]   | Lin SR, Chang CH, Hsu CF, et al. Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence. Br J Pharmacol 2020; 177(6): 1409-23.
[3]   | Sultana S, Asif HM, Nazar HM, Akhtar N, Rehman JU, Rehman RU. Medicinal plants combating against cancer--a green anticancer approach. Asian Pac J Cancer Prev. 2014; 15(11): 4385-94.
[4]   | Lichota A, Gwozdzinski K. Anticancer Activity of Natural Compounds from Plant and Marine Environment. Int J Mol Sci 2018; 19(11): 3533.
[5]   | Kabel AM, Atef A, Estfanous RS. Ameliorative potential of sitagliptin and/or resveratrol on experimentally-induced clear cell renal cell carcinoma. Biomed Pharmacother 2018; 97: 667-74.
[6]   | Mondal S, Bandyopadhyay S, Ghosh MK, Mukhopadhyay S, Roy S, Mandal C. Natural products: promising resources for cancer drug discovery. Anticancer Agents Med Chem 2012; 12(1): 49-75.
[7]   | Huang CY, Ju DT, Chang CF, Muralidhar Reddy P, Velmurugan BK. A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine (Taipei) 2017; 7(4): 23.
[8]   | Qamar H, Rehman S, Chauhan DK. Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cytotoxic Value. Curr Drug Targets 2019; 20(12): 1227-43.
[9]   | Khalifa SAM, Elias N, Farag MA, et al. Marine Natural Products: A Source of Novel Anticancer Drugs. Mar Drugs 2019; 17(9): 491.
[10]   | Aung TN, Qu Z, Kortschak RD, Adelson DL. Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action. Int J Mol Sci 2017; 18(3): 656.
[11]   | Fu B, Wang N, Tan HY, Li S, Cheung F, Feng Y. Multi-Component Herbal Products in the Prevention and Treatment of Chemotherapy-Associated Toxicity and Side Effects: A Review on Experimental and Clinical Evidences. Front Pharmacol 2018; 9: 1394.