eng Science and Education Publishing Journal of Cancer Research and Treatment 2374-2003 2020-06-02 8 2 11 14 10.12691/jcrt-8-2-1 JCRT2020821 article Ahmed M. Kabel ahmed.kabal@med.tanta.edu.eg 1 2 Maaly A. Abd Elmaaboud 2 Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia Resistance to the anticancer agents is a complex process that mainly results from alteration in the targets of the chemotherapeutic agents. Mechanisms that underlie resistance to the anticancer agents include inactivation of the drug, inhibition of cellular apoptosis, changes in the metabolic pathways of the drug, increased expression of the efflux proteins and enhancement of DNA repair and gene amplification. Several strategies were developed to overcome this resistance. The use of the combination chemotherapy is the best option for drug resistant types of cancer. This review throws light on resistance of cancer cells to the chemotherapeutic agents in view of the recent trends. http://pubs.sciepub.com/jcrt/8/2/1/jcrt-8-2-1.pdf cancer multi-drug resistance anticancer agents management