eng Science and Education Publishing Journal of Cancer Research and Treatment 2374-2003 2019-07-24 7 1 17 20 10.12691/jcrt-7-1-3 JCRT2019713 article Amal A. Alghorabi 1 Ahmed M. Kabel ahmed.kabal@med.tanta.edu.eg 2 3 Maaly A. Abd Elmaaboud 3 Pharm D, College of Pharmacy, Taif University, Taif, Saudi Arabia Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt Doxorubicin (DOX) is one of the anthracycline antibiotics that is used frequently for treatment of various types of malignancies including lung, breast and testicular cancers. DOX reacts with DNA by intercalation and inhibits the synthesis of DNA macromolecular components. Also, it may increase the production of free radicals which may contribute to its cytotoxicity. DOX may cause serious adverse effects including cardiotoxicity, hepatotoxicity and testicular toxicity. So, it has become increasingly important to find pharmacological remedies to protect against these serious adverse effects. This mini-review sheds light on DOX including its history, dynamics, clinical uses and adverse effects. http://pubs.sciepub.com/jcrt/7/1/3/jcrt-7-1-3.pdf doxorubicin dynamics uses toxicity