@article{jcrt2018621,
author={{P., Jayameena and K., Sivakumari and K., Ashok and S., Rajesh},
title={<i>In Silico </i>Molecular Docking Studies of Rutin Compound against Apoptotic Proteins (Tumor Necrosis Factor, Caspase-3, NF-Kappa-B, P53, Collagenase, Nitric Oxide Synthase and Cytochrome C)},
journal={Journal of Cancer Research and Treatment},
volume={6},
number={2},
pages={28--33},
year={2018},
url={http://pubs.sciepub.com/jcrt/6/2/1},
issn={2374-2003},
abstract={Rutin as a flavonoid compound contains many flavonoids having antitumor properties. Therefore, the present study was aimed to dock rutin compound with apoptotic proteins like TNF, Caspase-3, NF-Kappa-B, P53, Collagenase, Nitric Oxide Synthase and Cytohrome C by AutoDock software. The docking scores were highest in Nitric oxide synthase (-3.68 kcal/mol) followed by Tumor Necrosis Factor (-3.22 kcal/mol), Caspase-3 (-2.95 kcal/mol), Collagenase (-2.47 kcal/mol), Cytochrome C (-2.31 kcal/mol), NF-kappa-B (-1.8 kcal/mol) and P53 (-0.32 kcal/mol). The Log P value and lower hydrogen bond counts, confirming the ability of rutin compound for binding at the active sites of the receptor was determined by the <i>in silico</i> method. The potential drug candidate can further be validated by wet lab studies for its proper function.},
doi={10.12691/jcrt-6-2-1}
publisher={Science and Education Publishing}
}