eng Science and Education Publishing Journal of Cancer Research and Treatment 2374-2003 2016-12-09 4 5 88 95 10.12691/jcrt-4-5-3 JCRT2016453 article Nagham Nabil Omar 1 Mostafa Shaker Abolela 2 Marwa I. Abdelgawad esmailmarwa@yahoo.com 3 Abeer Ibrahim 4 Amr F. Mourad 5 Khalid Rezk 6 Radiology Department, Assuit University, Egypt Radiology Department, Nasser Institute Hospital Clinical Oncology Department, Assiut University, Egypt Medical Oncology Department, South Egypt Cancer Inistitute Radiodiagnosis Department, South Egypt Cancer Inistitute Surgical Oncology Department, South Egypt Cancer Inistitute Background: Treatment and prognosis of lymphoma depend on accurate staging and evaluation. Relapsed Lymphomas represent great problem in accurate quick diagnosis that imply appropriate treatment. Aim of the work: To evaluate diagnostic utility of 18F-FDG PECT/CT in assessment of treatment response and identification of disease relapse. Patients and Methods: This prospective study were conducted on 49 consecutive patients with histologically verified lymphoma. They were 27/49 (55.1%) male and 22/49 (44.9%) female aged 37.83±2.29. All patients were subjected to pretreatment as well a follow up clinical, laboratory, CT PET-CT. PET-CT findings were classified as positive and negative according to remission status and relapse. The sensitivity, specificity and accuracy of PET- CT in assessment of the remission status and relapse were calculated and to be confirmed by open or laparoscopic biopsy. Results: PET-CT detected complete regression in 28 patients (57.14%), partial regression in 4 patients (8.16%), stationary course in 2 patients (4.08%), progression / relapse in 15 patients (30.61%). According to PET/CT 9 (23%) patients were true positive, 25 (65%) were true negative and 5 (13%) were false negative with sensitivity, specificity, positive p predictive value and negative predictive value of 95% and 91%, 90% and 98%, respectively. Conclusion: Our results confirm FDG-PET as a valid tool for assessment of treatment response and detection of relapsing lymphoma. We recommended further multicentric prospective studies that incorporates a larger number of patients should be implemented to define the exact relation between certain clinical, pathological, laboratory and PET factors and fate of the disease. http://pubs.sciepub.com/jcrt/4/5/3/jcrt-4-5-3.pdf 18F-FDG PECT/CT lymphoma CT Treatment Relapsed Lymphoma