@article{jcrt2016453,
author={{Omar, Nagham Nabil and Abolela, Mostafa Shaker and Abdelgawad, Marwa I. and Ibrahim, Abeer and Mourad, Amr F. and Rezk, Khalid},
title={Diagnostic Utility of 18F-FDG PECT/CT in Assessment of Post-therapy Remission or Relapse of Lymphoma},
journal={Journal of Cancer Research and Treatment},
volume={4},
number={5},
pages={88--95},
year={2016},
url={http://pubs.sciepub.com/jcrt/4/5/3},
issn={2374-2003},
abstract={<b>Background:</b> Treatment and prognosis of lymphoma depend on accurate staging and evaluation. Relapsed Lymphomas represent great problem in accurate quick diagnosis that imply appropriate treatment. <b>Aim of</b> <b>the work</b><b>:</b><i><b> </b></i>To evaluate diagnostic utility of 18F-FDG PECT/CT in assessment of treatment response and identification of disease relapse. <b>Patients and Methods:</b> This prospective study were conducted on 49 consecutive patients with histologically verified lymphoma. They were 27/49 (55.1%) male and 22/49 (44.9%) female aged 37.83¡À2.29. All patients were subjected to pretreatment as well a follow up clinical, laboratory, CT PET-CT. PET-CT findings were classified as positive and negative according to remission status and relapse. The sensitivity, specificity and accuracy of PET- CT in assessment of the remission status and relapse were calculated and to be confirmed by open or laparoscopic biopsy. <b>Results:</b> PET-CT detected complete regression in 28 patients (57.14%), partial regression in 4 patients (8.16%), stationary course in 2 patients (4.08%), progression / relapse in 15 patients (30.61%). According to PET/CT 9 (23%) patients were true positive, 25 (65%) were true negative and 5 (13%) were false negative with sensitivity, specificity, positive p predictive value and negative predictive value of 95% and 91%, 90% and 98%, respectively. <i><b>Conclusion</b></i><b>:</b> Our results confirm FDG-PET as a valid tool for assessment of treatment response and detection of relapsing lymphoma. We recommended further multicentric prospective studies that incorporates a larger number of patients should be implemented to define the exact relation between certain clinical, pathological, laboratory and PET factors and fate of the disease.},
doi={10.12691/jcrt-4-5-3}
publisher={Science and Education Publishing}
}