@article{jcrt2016443,
author={{Kabel, Ahmed M. and Adwas, Almokhtar A. and Elkhoely, Abeer A. and Abdel-Rahman, Mohamed Nabih and Eissa, Amany A.},
title={Apoptosis: Insights into Pathways and Role of p53, Bcl-2 and Sphingosine Kinases},
journal={Journal of Cancer Research and Treatment},
volume={4},
number={4},
pages={69--72},
year={2016},
url={http://pubs.sciepub.com/jcrt/4/4/3},
issn={2374-2003},
abstract={Apoptosis or programmed cell death is characterized by certain morphological and biochemical characteristics. It is a vital process for normal cell turnover, proper development and functioning of the immune system, embryonic development and chemical-induced cell death. Disturbances of apoptosis play a key role in many diseases including neurodegenerative diseases, autoimmune disorders and many types of cancer. The field of apoptosis research has been moving forward at a rapid rate. Although many of the key proteins that play a role in apoptosis have been identified, the molecular mechanisms of action of these proteins had not been fully elucidated. The aim of this mini-review is to provide a general overview on the process of apoptosis including pathways, regulation, the role of apoptosis in health and disease as well as the role of p53, Bcl-2 and sphingosine kinase-1 in apoptosis.},
doi={10.12691/jcrt-4-4-3}
publisher={Science and Education Publishing}
}