@article{jcrt2016422,
author={{Adwas, Almokhtar A. and Elkhoely, Abeer A. and Kabel, Ahmed M. and Abdel-Rahman, Mohamed Nabih and Eissa, Amany A.},
title={Ameliorative Potential of Different Doses of Indol-3-carbinol on Doxorubicin-induced Cardiotoxicity in Mice},
journal={Journal of Cancer Research and Treatment},
volume={4},
number={2},
pages={26--31},
year={2016},
url={http://pubs.sciepub.com/jcrt/4/2/2},
issn={2374-2003},
abstract={<i>Background:</i> Doxorubicin (DOX) is a commonly used chemotherapeutic agent that is associated with serious dose-limiting cardiotoxicity. This cardiotoxicity was attributed to various mechanisms including induction of oxidative stress and inflammation together with inhibition of apoptosis. Indole-3-carbinol (I3C) is a phytochemical that was suggested to have potent anti-oxidant and anti-inflammatory properties. <i>Aim:</i> It was to detect the possible ameliorative effects of different doses of I3C on doxorubicin-induced cardiotoxicity in mice. <i>Methods:</i> Eighty mice were divided into four equal groups: control untreated group; DOX group; DOX + I3C 1000 ppm group and DOX + I3C 2000 ppm group. Survival rate, serum creatine kinase (CK-MB), lactate dehydrogenase (LDH) and troponin I were measured. Also, tissue malondialdehyde (MDA), tissue catalase (CAT), tissue glutathione peroxidase (GPx), and tissue tumor necrosis factor alpha (TNF-¦Á) were determined. Parts of the heart were subjected to histopathological examination. <i>Results:</i> I3C produced dose-dependent significant increase in the survival rate, tissue GPx and CAT with significant decrease in serum CK-MB, LDH, troponin I, tissue MDA and TNF-¦Á and improved the histopathological and immunohistochemical changes compared to DOX-treated group. <i>Conclusion:</i> I3C- in a dose dependent manner- had a protective effect against doxorubicin-induced cardiotoxicity in mice.},
doi={10.12691/jcrt-4-2-2}
publisher={Science and Education Publishing}
}