@article{jcrt2014212,
author={{ElAmrani, Amal and Moumad, Khalid and Attaleb, Mohammed and Benhassou, Mustapha and F?rsti, Asta and Ennaji, Moulay Mustapha and Mzibri, Mohammed El and Khyatti, Meriem},
title={Absence of CHEK2 1100delC, R145W and I157T Mutations in Breast Cancer in a Moroccan Population},
journal={Journal of Cancer Research and Treatment},
volume={2},
number={1},
pages={6--9},
year={2014},
url={http://pubs.sciepub.com/jcrt/2/1/2},
abstract={Mutations in the <i>BRCA1</i><i> </i>and <i>BRCA2</i><i> </i>genes confer a high risk of breast cancer (BC), although they account for only a small fraction of BC susceptibility. Rare mutations in genes conferring moderate risk may contribute to BC risk. Previous studies have shown that mutations in the <i>CHEK2</i> gene, which encodes for an upstream regulator of <i>BRCA1</i>, may cause a moderately increased BC risk. In the current study we investigated the status of three founder mutations in the <i>CHEK2</i> gene (c.1100delC, R145W and I157T) using direct sequencing in 50 BC and 50 control samples. No mutations were detected. This result is in line with the postulated existence of a c.1100delC frequency gradient from the North to the South in Europe with higher frequencies in the Northern countries.},
doi={10.12691/jcrt-2-1-2}
publisher={Science and Education Publishing}
}