Science and Education Publishing International Journal of Physics 2333-4576 2 1 2014 02 24 Unified Field Theory and Topology of Nuclei 15 22 EN Zhiliang Cao Wayne State University, 42 W Warren Ave, Detroit Henry Gu Cao IJP2014214 10.12691/ijp-2-1-4 2014 02 02 2014 02 23 2014 02 24 This paper proposes that a nucleus has a lattice configuration. A nucleus can not be seen visually. The configuration of a nucleus is studied in theoretical models, such as lattice, NCFC, and water drop. There are a few theories study many body interactions in a nucleus, such as Ab initio calculation, BCS formalism, and SEMF. However, the precise structure of an isotope is not known. According to Unified Field Theory (UFT), a proton has the shape of an octahedron. Since the strong forces are along the axes of the octahedron of protons and neutron, the structure of ground state isotopes of any given element can be logically induced. Furthermore, only two of three axes of the octahedron nucleus possess interactive forces. Therefore, any nuclear structure has one layer only. Our results demonstrate that there is a configuration for any isotope. Mass, stability and configuration of an isotope are related. We anticipate our essay to be a starting point of new method that provides precise configuration for each isotope, theoretical mass calculation for an unknown isotope, and nuclear characteristics/stability analysis for a given configuration. For example, the best symmetrical lattice of an isotope can be selected from all possible lattices. The selected lattice for the isotope can decide the stability of the isotope.