Science and Education Publishing International Journal of Hematological Disorders 3 1 2017 3 13 Idiopathic CD4+ Lymphocytopenia Associated with EvansĄŻ Syndrome: A Case Report 1 2 EN Ines Safra University of Tunis El Manar, Medecine Tunis Faculty, HMC Laboratory, Pasteur Institute of Tunisia Imene Namouchi HMC Laboratory Salem Abbes Samia Mnif IJHD2017311 10.12691/ijhd-3-1-1 2016 10 21 2017 2 1 2017 3 11 Idiopathic CD4+ lymphocytopenia (ICL) is a syndrome first defined in 1992 by the Centers for Disease Control and Prevention (CDCP) as Ą°a documented absolute CD4 T lymphocyte count of less than 300 cells per cubic millimeter or of less than 20% of total T cells on more than one occasion, no evidence of infection on HIV testing and the absence of any defined immunodeficiency or therapy associated with depressed levels of CD4 T cellsĄ±. The clinical course, immunologic characteristics, CD4 T cell kinetics, long term outcome and prognosis of this syndrome remain poorly defined but it is widely accepted that ICL is a rare, heterogeneous syndrome, usually detected after the occurrence of an opportunistic infection in a person without known immunodeficiency or immunodepression although it can also be an incidental laboratory finding. Autoimmune phenomena are common in this syndrome. In this article, we reported a case diagnosed with an EvansĄŻ syndrome and that fulfilled the CDCP definition of ICL.