Science and Education Publishing International Journal of Hematological Disorders 1 1A 2014 12 09 Is There Still a Role for High-Dose Melphalan and Stem Cell Transplantation in the Treatment of Multiple Myeloma? 7 12 EN Morie A. Gertz Department of Medicine, College of Medicine, Mayo Distinguished Clinician, Rochester Francis K. Buadi Martha Q. Lacy IJHD201411A2 10.12691/ijhd-1-1A-2 2014 09 25 2014 11 11 2014 12 09 Stem cell transplantation was demonstrated to have a survival value in the era prior to the introduction of novel agents for the treatment of multiple myeloma. It has become reasonable to begin to question the value of stem cell transplantation. In this review, we analyzed available data and ongoing trials to determine whether or not the evidence is sufficient to continue using stem cell transplantation as a primary modality for the treatment of the eligible patient with multiple myeloma.