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Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

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American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
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Biomedical Science and Engineering

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Science and Education Publishing (http://www.sciepub.com)

Preface for the Special Issue

Yossi Cohen

Abstract:

Keywords:

Received September 25, 2014; Revised November 11, 2014; Accepted December 09, 2014

Citation: Yossi Cohen, Preface for the Special Issue. International Journal of Hematological Disorders, 1 (1A). 0-0. January 2014. doi:10.12691/ijhd-1-1A-0

Plasma cells are terminally differentiated B cells which normally secret immunoglobulins. The group of plasma cell disorders consistsof several sub-categories including monoclonal gammopathy of unknown significance (MGUS), primary amyloidosis, the polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndromeas well as multiple myeloma (MM). The latter category is subdivided into symptomatic versus asymptomatic myeloma and is also stratified by clinical prognostic scores such as the old Durie-Salmon classification and the newer international scoring system (ISS), as well as according to reproducible chromosomal abnormalities and more recently also by high versus low-risk gene expression profile (GEP). The clinical manifestations of transformed plasma cells are mainly derived from the local effects of the tumor cells proper and from the impact of the circulating monoclonal immunoglobulins. The last decades brought with them an exciting breakthrough in drug development for MM with improved outcome of patients but they also left many issues unresolved, including the preferred method for the detection of minimal residual disease (MRD) (e.g., based on the immunoglobulin gene rearrangement or immunophenotype), the role of maintenance therapy and many additional open questions. The following Special Issue is touching some aspects in the pathophysiology, diagnosis and treatment of some of the plasma cell disorders and is also deals with the obscure mechanism of action of the IMiDs, the latter started the era of novel agents against myeloma with the introduction of thalidomide.