@article{ijhd2014112,
author={{Ajjack, Eman A. and Awooda, Hiba A. and Abdalla, Sana Eltahir},
title={Haemoglobin Patterns in Patients with Sickle Cell Haemoglobinopathies},
journal={International Journal of Hematological Disorders},
volume={1},
number={1},
pages={8--11},
year={2014},
url={http://pubs.sciepub.com/ijhd/1/1/2},
abstract={<b>Background:</b> Hemoglobinopathy is a group of inherited disorders characterized by structural variations of the hemoglobin molecule; and sickle cell disease constitutes one of the major genetic blood disorders in Sudan. The aim of this study was to determine the haemoglobin patterns of patients with sickle cell haemoglobinopathies. <b>Methods:</b> Blood samples were collected from 70 subjects diagnosed or suspected to have sickle cell disease. Blood samples were also taken from 30 control patients. Screening was done by sickling test and capillary electrophoresis was done. <b>Results:</b> 37 patients (52.9%) showed AS, 1 patient (1.4%) showed AS/C, 8 patients (11.4%) showed S/?Thalassaemia, 1 patient (1.4%) showed S/C, 3 patients (4.3%) showed S/D and 20 patients (28.6%) showed SS. The mean level of Hb showed lower level in patients group while HbA2 showed no significant change and HbF and HbS showed different levels according to the type of haemoglobinopathy. <b>Conclusion:</b> Different variants of sickle cell haemoglobinopathies were identified; AS, AS/C, S/?Thalassaemia, S/C, S/D and SS patterns were reported. Haemoglobin A2 have no significant difference in patients with sickle cell disease, while Hb F and Hb S show significant elevation.},
doi={10.12691/ijhd-1-1-2}
publisher={Science and Education Publishing}
}